Manchester United are chasing their second Europa League title and first in four seasons.
The Dutch side are one of only two remaining teams in the tournament to have won the title previously.
After a final heart-break in 2019, Arsenal will want to get their hands on the elusive title.
The high-flying Spanish side will be making their maiden Europa League quarter-final appearance.
Paulo Fonseca-coached AS Roma have made the Europa League quarter-final for the first time in many seasons and will want to go the distance.
The Croatian side shocked Tottenham Hotspur to make 3-2 to make the UEL quarter-final for the first time.
Unai Emery’s Villarreal are searching for their maiden Europa League title after three semi-final defeats.
The Czech giants have reached successive Europa League quarter-finals for the first time in their history. They have never made it to the final.