The Indian benchmark indices opened over 400 points up on Wednesday amid positive global cues, as buying was seen in the IT, auto and pharma sectors in the early trade. At around 9.25 am, Sensex was trading 445.6 points or 0.54 per cent up at 82,500.73 while the Nifty added 130.15 point or 0.52 per cent at 25,174.50