Illinois [US], January 27 (ANI): New research presented at the 2025 Society of Thoracic Surgeons (STS) Annual Meeting reveals that anatomic lung resections, such as lobectomy and segmentectomy, are associated with better long-term survival than wedge resection for patients with early-stage non-small cell lung cancer (NSCLC).

The study analysed outcomes for more than 32,000 stage 1A NSCLC patients using data from the STS General Thoracic Surgery Database (STS GTSD), with long-term follow-up linked to the National Death Index and Centers for Medicare and Medicaid Services database, which provides up to 10 years of survival data.

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Lobectomy for stage 1A NSCLC offered the highest survival rates, with a 5-year overall survival (OS) of 71.9 per cent and 10-year OS of 44.8 per cent. Segmentectomy, which resulted in a 5-year OS of 69.6 per cent and a 10-year OS of 44.2 per cent, proved to be a viable alternative. Both lobectomy and segmentectomy demonstrated better outcomes than wedge resection, which had a 5-year OS of 66.3 per cent and a 10-year OS of 41.4 per cent.

This research highlights the profound effect of using real-world data to provide critical insights that complement findings from randomised controlled trials (RCTs). While RCTs suggest an equivalence between lobectomy and sub-lobar resections, this real-world study offers clinicians additional insight. It provides a broader perspective applicable to diverse patient populations and healthcare settings.

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"This study reinforces the need for nuanced decision-making, integrating both RCTs and real-world data to deliver the highest quality of care," said Christopher Seder, MD, a thoracic surgeon at Rush University Medical Center, Chicago. "By analyzing outcomes in a variety of healthcare settings, we can offer informed recommendations, ultimately improving patient outcomes across the board."

The findings come at a pivotal time when cardiothoracic surgical practices are evolving rapidly, integrating innovative tools and approaches that prioritize patient safety and long-term health. Dr Seder added, "This research is a significant step forward in understanding the long-term implications of surgical choices for lung cancer patients. Using real-world data to complement RCT findings offers surgeons additional context for tailoring treatment strategies." (ANI)

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