Washington [US], November 14 (ANI): Type I interferon (IFN) is a strong immune activator found in high concentrations in the majority of patients with lupus, an autoimmune disease. In Arthritis & Rheumatology, researchers report positive results from the first placebo-controlled long-term trial of anifrolumab, a human monoclonal antibody that targets the type I IFN receptor, in lupus patients.

In the long-term extension trial of two earlier phase 3 trials, patients continued anifrolumab 300 mg, switched from anifrolumab 150 mg to 300 mg, or were re-randomized from placebo to either anifrolumab 300 mg or continued placebo, administered every 4 weeks, with all patients also receiving standard therapy. Anifrolumab was administered as an intravenous infusion.

Also Read | World Diabetes Day 2022 Date and Theme: Know History and Significance of This Important Health Day.

Treatment with anifrolumab was well tolerated and had an acceptable long-term safety profile, while sustaining reduction in lupus disease activity and reducing or eliminating the need for steroid medications.

"Managing systemic lupus erythematosus is challenging, due to the complexity of the disease itself, as well as from treatments like oral corticosteroids that can reduce disease activity, but also place a significant burden on patients when used in high doses long-term," said corresponding author Hussein Al-Mossawi, MD, PhD, of AstraZeneca. "These new data from the TULIP extension trial--the longest placebo-controlled clinical trial performed in lupus to date--support the benefit-risk profile of anifrolumab seen in previous trials, now over four years." (ANI)

Also Read | What The Hell Navya: Jaya Bachchan Opens Up About Changing Sanitary Pads Behind Bushes During Outdoor Shoots, Says 'It Was Awkward and Embarrassing'.

(The above story is verified and authored by ANI staff, ANI is South Asia's leading multimedia news agency with over 100 bureaus in India, South Asia and across the globe. ANI brings the latest news on Politics and Current Affairs in India & around the World, Sports, Health, Fitness, Entertainment, & News. The views appearing in the above post do not reflect the opinions of LatestLY)