Munich [Germany], January 25 (ANI): Breathing is the most persistent and essential bodily rhythm which exerts a strong physiological effect on the autonomous nervous system. It has been known to modulate a wide range of cognitive functions such as perception, attention, and thought structure. However, the mechanisms of its impact on cognitive function and the brain are largely unknown.

Now, a new research led by Ludwig Maximilian University (LMU) neuroscientists has shown that breathing coordinates neuronal activity throughout the brain during sleep and quiet.

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While we sleep, the brain does not get switched off, but becomes busy with "saving" the important memories of the day. To achieve that, brain regions are synchronized to coordinate the transmission of information between them.

Yet, the mechanisms that enabled this synchronization across multiple remote brain regions are not well understood. Traditionally, these mechanisms were sought in correlated activity patterns within the brain. However, LMU neuroscientists Prof. Anton Sirota and Dr Nikolas Karalis were able to show that breathing acted as a pacemaker that entrained the various brain regions and synchronized them with each other.

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The scientists performed large-scale in vivo electrophysiological recordings in mice, from thousands of neurons across the limbic system. They showed that respiration entrains and coordinates neuronal activity in all investigated brain regions -- including the hippocampus, medial prefrontal and visual cortex, thalamus, amygdala, and nucleus accumbens -- by modulating the excitability of these circuits in olfaction-independent way.

"Thus, we were able to prove the existence of a novel non-olfactory, intracerebral, mechanism that accounts for the entrainment of distributed circuits by breathing, which we termed "respiratory corollary discharge," said Karalis, who is currently research fellow at the Friedrich Miescher Institute for Biomedical Research in Basel. "Our findings identify the existence of a previously unknown link between respiratory and limbic circuits and are a departure from the standard belief that breathing modulates brain activity via the nose-olfactory route," underlined Sirota.

This mechanism mediated the coordination of sleep-related activity in these brain regions, which is essential for memory consolidation and provides the means for the co-modulation of the cortico-hippocampal circuits synchronous dynamics. According to the authors, these results represented a major step forward and provide the foundation for new mechanistic theories, that incorporated the respiratory rhythm as a fundamental mechanism underlying the communication of distributed systems during memory consolidation. (ANI)

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