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Nobel Prize in Physiology or Medicine 2025: Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi Receive Award for Discoveries in Peripheral Immune Tolerance

The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking discoveries on peripheral immune tolerance. Their research revealed how the immune system distinguishes the body’s own cells from harmful invaders, preventing autoimmune diseases.

Published: Oct 06, 2025 03:35 PM IST
Nobel Prize in Physiology or Medicine 2025: Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi Receive Award for Discoveries in Peripheral Immune Tolerance
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The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking discoveries on peripheral immune tolerance. Their research revealed how the immune system distinguishes the body’s own cells from harmful invaders, preventing autoimmune diseases. Brunkow and Ramsdell discovered mutations in the Foxp3 gene, explaining severe autoimmune disorders in mice and humans. Sakaguchi later linked this gene to regulatory T cells, a class of immune cells he identified, which monitor and control other immune cells. These findings have opened new avenues for treatments in cancer, autoimmune disorders, and organ transplantation. The laureates will equally share the 11 million Swedish kronor prize. Nobel Peace Prize 2025: From Mahatma Gandhi to Jawaharlal Nehru, Check Full List of Indians Who Have Won or Been Nominated for the Nobel Peace Prize As Pakistan and Israel Nominate US President Donald Trump for 2025 Award.

Nobel Prize in Physiology or Medicine 2025:

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